MOTS-c: The Mitochondrial Encoded Hormone Revolutionizing Our View of Metabolism and Aging

MOTS-c is a mitochondria-derived peptide (MDP) known for its remarkable effects on metabolic regulation, fat loss, and cellular resilience. Encoded within mitochondrial DNA, MOTS-c enhances the body’s response to metabolic stress by activating AMPK and supporting glucose utilization and fat oxidation. This peptide is recognized for promoting energy efficiency, weight management, and healthy aging, making it a unique tool in the field of metabolic and longevity research.

MOTS-c delivers a mitochondrial-based approach to metabolic optimization and anti-aging, ideal for those targeting fat reduction, energy balance, and cellular performance.

What Is MOTS-c and How Does It Work?

MOTS-c is a 16-amino-acid peptide that acts as a key regulator of cellular energy metabolism. It helps the body adapt to metabolic stress — such as fasting, exercise, or calorie restriction — by activating pathways that increase glucose utilization, enhance fat oxidation, and improve insulin sensitivity.

Mechanistically, MOTS-c works through the AMPK (AMP-activated protein kinase) signaling pathway — the same cellular switch activated by exercise or caloric restriction. This pathway promotes energy balance, encourages the body to use stored fat for fuel, and enhances metabolic flexibility.

Key Benefits:

• Fat Loss Support: Enhances fat oxidation and reduces fat storage by activating AMPK.
• Improved Glucose Metabolism: Increases insulin sensitivity and supports stable blood sugar.
• Cellular Stress Resistance: Helps cells adapt to oxidative and metabolic stress.
• Mitochondrial Health: Promotes efficient energy production and mitochondrial biogenesis.
• Longevity Potential: Mimics effects of exercise and calorie restriction at the cellular level.

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a synthetic 16-amino-acid mitochondrial-derived peptide (MDP) encoded by the 12S rRNA region of mitochondrial DNA. It is used in in vitro and in vivo experimental models to study metabolic regulation, cellular bioenergetics, and stress response pathways. MOTS-c continues to be of interest in preclinical research focused on mitochondrial signaling and cellular adaptation under metabolic stress conditions.