MK-677 (Ibutamoren)

MK-677 (Ibutamoren) is a non-peptide ghrelin receptor agonist that mimics the action of endogenous ghrelin by binding to the growth hormone secretagogue receptor (GHS-R1a). This interaction influences various metabolic and enzymatic pathways involved in molecular signaling.

Key Areas of Research and Mechanistic Insights

1. Growth Hormone and IGF-1 Modulation
   Laboratory models show that MK-677 promotes sustained elevations in GH and IGF-1 levels for several hours, supporting research into hormonal rhythms and pituitary regulation.

2. Metabolic and Energy Balance Studies
   Researchers study MK-677’s influence on protein synthesis, nitrogen retention, and energy metabolism, helping to better understand how GH pathways affect muscle and fat metabolism.

3. Bone and Muscle Physiology
   Scientific interest includes MK-677’s potential role in bone remodeling and muscle preservation — critical areas of study in age-related physiology and rehabilitation science.

4. Sleep and Circadian Rhythm Research
   Because GH release is linked to deep sleep cycles, MK-677 is often used in experiments examining the connection between neuroendocrine function and circadian regulation.

How do MK-677 Ibutamoren  Work? potentially

MK-677, also known as Ibutamoren, functions by mimicking the action of ghrelin, a hormone that potentially facilitates pituitary-mediated GH secretion. It interacts with central ghrelin receptor (GHSR1a) sites, specifically the growth hormone secretagogue receptor (GHSR). Activation of these receptors prompts the pituitary gland to potentially enhance pulsatile GH output.

Additionally, MK-677 modulates hepatic IGF-1 biosynthesis, which plays a key function in anabolism, skeletal integrity, and systemic metabolism. By stimulating both GH and IGF-1, MK-677 initiates catabolic-to-anabolic transition cascades, contributing to potentially increased muscle mass, improved bone density, and accelerated tissue regeneration and reparative signaling.

Properties of MK-677 Ibutamoren Capsules

• MK 677 Ibutamoren Capsules are offered as 20mg/60ct/1.2g
• CAS Number is stated as 159634-47-6
• Molar Mass is 528.67 g·mol−1
• It has a Chemical Formula of C27H36N4O5S
• IUPAC Name is 2-amino-2-methyl-N-[1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide
• Also known by Synonyms as MK-677; MK-0677; L-163,191; Oratrope
• Available in 20 mg/30 ct/600 mg and 20 mg/60 ct/1.2 g